rs1541924

This is a regulatory region variant variant in the ANGPTL8 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

triglyceride measurement

Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)

Allele C

OR 0.08

p 8.0e-22

N 99,432

Large GWAS

African American or Afro-Caribbean, African unspecified

About ANGPTL8

Predicted to enable hormone activity. Involved in regulation of lipid metabolic process and triglyceride homeostasis. Acts upstream of or within positive regulation of protein processing and regulation of lipoprotein metabolic process. Located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

View all ANGPTL8 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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