rs1554638200
This variant is located in the PSCA gene.
▶ClinVar annotation
▶Research that mentions this SNP (1)
▶Two genetic variants in prostate stem cell antigen and gastric cancer susceptibility in a chinese populationAssociationN=2,756Chen Wu et al.(2009)· Molecular Carcinogenesis
Case-control study of 1020 NCGC patients, 716 CGC patients, and 1020 controls in Chinese population examined associations of two PSCA SNPs with gastric cancer risk. rs2294008T allele was associated with increased noncardia gastric carcinoma (NCGC) risk (OR=1.35, 95% CI=1.13-1.61), and rs2976392A allele showed borderline increased risk (OR=1.20, 95% CI=1.01-1.43). The increased risk was restricted to female subjects, and both SNPs were associated with poorly differentiated and high-stage NCGC at diagnosis. No associations were detected for cardia gastric carcinoma (CGC).
About PSCA
This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
View all PSCA variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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