PSCA
prostate stem cell antigen
Summary
This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Known Variants34 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs149355590 | 8:143,751,771 | G/A | coding sequence variant | — |
| rs2978974 | 8:143,751,864 | G/A | coding sequence variant | — |
| rs9297976 | 8:143,752,235 | T/C | upstream gene variant | — |
| rs2976384 | 8:143,752,994 | T/A | — | — |
| rs147044195 | 8:143,754,529 | C/T | intron variant | — |
| rs2920286 | 8:143,754,728 | G/A | intron variant | — |
| rs587697607 | 8:143,755,512 | C/T | — | — |
| rs34635647 | 8:143,756,890 | A/G | — | — |
| rs2920283 | 8:143,757,037 | T/C | regulatory region variant | — |
| rs2978981 | 8:143,759,137 | C/G | — | — |
| rs2976387 | 8:143,759,364 | G/A | upstream gene variant | — |
| rs142914096 | 8:143,759,383 | C/T | upstream gene variant | — |
| rs11786721 | 8:143,760,179 | T/A | — | — |
| rs2976388 | 8:143,760,256 | G/A | upstream gene variant | — |
| rs2920281 | 8:143,760,444 | C/G | — | — |
| rs2920280 | 8:143,761,144 | G/T | — | — |
| rs587637031 | 8:143,761,505 | G/A | coding sequence variant | — |
| rs2294008 | 8:143,761,931 | C/T | coding sequence variant | benign |
| rs1554638200 | 8:143,761,978 | C/T | — | uncertain significance |
| rs2920279 | 8:143,762,135 | A/T | coding sequence variant | — |
| rs2976391 | 8:143,762,724 | C/G | regulatory region variant | — |
| rs781929366 | 8:143,762,785 | C/A | — | uncertain significance |
| rs1814631554 | 8:143,762,823 | T/G | — | uncertain significance |
| rs587651896 | 8:143,762,839 | G/C | — | uncertain significance |
| rs2976392 | 8:143,762,932 | G/T | — | — |
| rs587742470 | 8:143,763,447 | A/C | — | uncertain significance |
| rs1554638436 | 8:143,763,458 | G/A | — | uncertain significance |
| rs782238843 | 8:143,763,480 | A/T | — | uncertain significance |
| rs2978982 | 8:143,763,490 | T/G | synonymous variant | — |
| rs1374261806 | 8:143,763,507 | T/C | — | uncertain significance |
| rs369384796 | 8:143,763,539 | G/A | — | likely benign |
| rs1045531 | 8:143,763,547 | C/A | synonymous variant | — |
| rs2976393 | 8:143,763,618 | C/T | — | — |
| rs10216533 | 8:143,763,690 | G/A | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.