rs2978974
This is a coding sequence variant variant in the PSCA gene.
▶Research that mentions this SNP (1)
▶Systematic evaluation of bladder cancer risk‐associated single‐nucleotide polymorphisms in a chinese populationAssociationN=212Zhicheng Ma et al.(2013)· Molecular Carcinogenesis
Case-control study of PSCA rs2294008 C/T polymorphism in 107 South Indian urothelial bladder cancer patients and 105 controls. The CT heterozygous genotype conferred 2.77-fold increased risk (p<0.0001), and the T allele showed 3.35-fold risk (OR=3.349, p<0.0001). Risk was significantly elevated in smokers (OR CT/TT=2.374) and inversive tumors (OR CT/TT=2.658), suggesting rs2294008 as a susceptibility marker for bladder carcinogenesis.
About PSCA
This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
View all PSCA variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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