rs2976391

This is a regulatory region variant variant in the PSCA gene.

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Research that mentions this SNP (1)

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The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a meta-analysis
Meta-analysisN=19,904Danni Shi et al.(2012)· Journal of Cancer Research and Clinical Oncology

A meta-analysis of 9 case-control studies (10,746 cases, 9,158 controls) found that PSCA rs2294008 C>T and rs2976392 G>A polymorphisms are significantly associated with increased gastric cancer risk, with ORs of 1.61 (95% CI 1.35-1.91) and 1.69 (95% CI 1.24-2.31) respectively. The association was particularly strong for non-cardia and diffuse-type gastric cancer subtypes in both Asian and European populations.

Traits studied:Diffuse-type gastric cancerGastric cancerIntestinal-type gastric cancerNon-cardia gastric cancer
PubMedDOIMetascience Observatory

About PSCA

This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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