rs16948048

This is a regulatory region variant variant in the ZNF652 gene.

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GWAS Catalog Trait Associations (8)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body height

Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)

Allele G

OR 0.03

p 4.0e-22

N 472,730

Large GWAS

East Asian

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.02

p 2.0e-14

N 165,056

Large GWAS

East Asian

coronary artery disease

van der Harst P et al. “Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.” Circulation Research 122(3):433-443 (2018)

Allele A

OR 0.05

p 3.0e-16

N 250,736

Large GWAS

asthma

Jia G et al. “Discerning asthma endotypes through comorbidity mapping.” Nature Communications 13(1):6712 (2022)

Allele G

OR 1.06

p 7.0e-14

N 305,098

Large GWAS

multi-ancestry

systolic blood pressure

Hoffmann TJ et al. “Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.” Nature Genetics 49(1):54-64 (2017)

Allele A

OR 0.27

p 5.0e-12

N 321,262

Large GWAS

multi-ancestry

atopic eczema

Ellinghaus D et al. “High-density genotyping study identifies four new susceptibility loci for atopic dermatitis.” Nature Genetics 45(7):808-12 (2013)

Allele G

OR 1.17

p 3.0e-9

N 7,874

Large GWAS

European

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.09

p 4.0e-8

N 649,402

Large GWAS

multi-ancestry

cryptic phenotype measurement

Blair DR et al. “Common genetic variation associated with Mendelian disease severity revealed through cryptic phenotype analysis.” Nature Communications 13(1):3675 (2022)

Allele G

OR 0.01

p 2.0e-8

N 308,095

Large GWAS

European

diastolic blood pressure

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.02

p 8.0e-13

N 609,354

Major Consortium StudyLarge GWAS

multi-ancestry

Hoffmann TJ et al. “Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.” Nature Genetics 49(1):54-64 (2017)

Allele G

OR 0.27

p 4.0e-13

N 99,785

Large GWAS

multi-ancestry

Newton-Cheh C et al. “Genome-wide association study identifies eight loci associated with blood pressure.” Nature Genetics 41(6):666-76 (2009)

Allele G

OR 0.31

p 5.0e-9

N 34,433

Large GWAS

multi-ancestry

diastolic blood pressure change measurement

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele A

OR 0.02

p 1.0e-11

N 609,486

Major Consortium StudyLarge GWAS

multi-ancestry

About ZNF652

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

rs16948048

GWAS Catalog Trait Associations (8)

body height

coronary artery disease

asthma

systolic blood pressure

atopic eczema

cryptic phenotype measurement

diastolic blood pressure

diastolic blood pressure change measurement

About ZNF652

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