rs16980091

This variant is located in the FOXA3 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Beta blocking agent use measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele T

OR 0.06

p 1.0e-8

N 178,726

Large GWAS

East Asian

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ClinVar annotation

Benign

1 submitter

FOXA3-related disorder

View on ClinVar →

About FOXA3

This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. [provided by RefSeq, Jul 2008]

View all FOXA3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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