rs16998073

This is a upstream gene variant variant.

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GWAS Catalog Trait Associations (28)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

red blood cell density

Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)
Allele T
OR 0.03
p 5.0e-39
N 545,203
Large GWAS
European

fibroblast growth factor 5 level

Kalnapenkis A et al. “Genetic determinants of plasma protein levels in the Estonian population.” Scientific Reports 14(1):7694 (2024)
Allele T
OR 0.59
p 8.0e-34
N 489
Small GWAS
European

aging

Lin WY et al. “Lifestyle Factors and Genetic Variants on 2 Biological Age Measures: Evidence From 94 443 Taiwan Biobank Participants.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 77(6):1189-1198 (2022)
Allele T
OR 0.10
p 6.0e-26
N 25,460
Large GWAS
East Asian

cryptic phenotype measurement

Blair DR et al. “Common genetic variation associated with Mendelian disease severity revealed through cryptic phenotype analysis.” Nature Communications 13(1):3675 (2022)
Allele T
OR 0.01
p 5.0e-24
N 308,095
Large GWAS
European

blood protein amount

Hillary RF et al. “Multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults.” Genome Medicine 12(1):60 (2020)
Allele T
OR 0.50
p 6.0e-22
N 982
Small GWAS
European

preeclampsia, hypertension, pregnancy-induced

Tyrmi JS et al. “Genetic Risk Factors Associated With Preeclampsia and Hypertensive Disorders of Pregnancy.” Jama Cardiology 8(7):674-683 (2023)
Allele T
OR 1.14
p 6.0e-19
N 130,207
Large GWAS
European

hemoglobin measurement

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.02
p 4.0e-17
N 407,887
Major Consortium StudyLarge GWAS
European
Timoteo VJ et al. “Common and ethnic-specific genetic determinants of hemoglobin concentration between Taiwanese Han Chinese and European Whites: findings from comparative two-stage genome-wide association studies.” The Journal of Nutritional Biochemistry 111:109126 (2023)
Allele A
OR —
β 0.021
p 1.0e-8
N 52,141
Large GWAS
European

hematocrit

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.02
p 8.0e-16
N 407,836
Major Consortium StudyLarge GWAS
European

preeclampsia

Tyrmi JS et al. “Genetic Risk Factors Associated With Preeclampsia and Hypertensive Disorders of Pregnancy.” Jama Cardiology 8(7):674-683 (2023)
Allele T
OR 1.12
p 1.0e-15
N 593,648
Large GWAS
European, Central Asian
Honigberg MC et al. “Polygenic prediction of preeclampsia and gestational hypertension.” Nature Medicine 29(6):1540-1549 (2023)
Allele T
OR 1.11
p 2.0e-15
N 455,887
Large GWAS
multi-ancestry
Pujol Gualdo N et al. “Atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses.” Nature Medicine 31(5):1626-1634 (2025)
Allele T
OR 0.88
p 4.0e-14
N 294,039
Large GWAS
European

pulse pressure measurement

Hoffmann TJ et al. “Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.” Nature Genetics 49(1):54-64 (2017)
Allele A
OR 0.23
p 1.0e-15
N 321,262
Large GWAS
multi-ancestry
Takeuchi F et al. “Interethnic analyses of blood pressure loci in populations of East Asian and European descent.” Nature Communications 9(1):5052 (2018)
Allele A
OR 0.41
p 2.0e-12
N 130,777
Large GWAS
multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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