Trait
SNPs associated with Preeclampsia
36 genetic variants across 15 genes have been associated with Preeclampsia in published research. Key genes include ACE, AGT, CBS.
Associated variants36 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs699 | AGT | Increased risk of preeclampsia | Meta-analysis |
| rs1800629 | TNF | Increased risk of preeclampsia during pregnancy | Meta-analysis |
| rs6025 | F5 | Increased preeclampsia risk in pregnancy | Meta-analysis |
| rs1801133 | MTHFR | Increased preeclampsia risk | Meta-analysis |
| rs16998073 | — | GWAS association (p=1.0e-15) | Large GWAS |
| rs259983 | — | GWAS association (p=1.0e-15) | Large GWAS |
| rs260017 | — | GWAS association (p=1.0e-13) | Large GWAS |
| rs74715624 | ZNF831 | GWAS association (p=2.0e-13) | Large GWAS |
| rs1421085 | FTO | GWAS association (p=3.0e-13) | Large GWAS |
| rs7318880 | — | GWAS association (p=2.0e-12) | Large GWAS |
| rs10774624 | LINC02356 | GWAS association (p=1.0e-11) | Large GWAS |
| rs9855086 | MECOM | GWAS association (p=2.0e-11) | Large GWAS |
| rs167479 | — | GWAS association (p=2.0e-11) | Large GWAS |
| rs2508372 | — | GWAS association (p=3.0e-11) | Large GWAS |
| rs2653414 | — | GWAS association (p=3.0e-11) | Large GWAS |
| rs12656497 | — | GWAS association (p=8.0e-11) | Large GWAS |
| rs149764880 | CLCN6 | GWAS association (p=9.0e-11) | Large GWAS |
| rs2208589 | — | GWAS association (p=1.0e-10) | Large GWAS |
| rs6026744 | ZNF831 | GWAS association (p=1.0e-10) | Large GWAS |
| rs7139122 | — | GWAS association (p=2.0e-10) | Large GWAS |
| rs13154066 | — | GWAS association (p=5.0e-10) | Large GWAS |
| rs17367504 | MTHFR | GWAS association (p=5.0e-10) | Large GWAS |
| rs3018700 | — | GWAS association (p=1.0e-09) | Large GWAS |
| rs779463 | — | GWAS association (p=2.0e-09) | Large GWAS |
| rs2596471 | — | GWAS association (p=2.0e-09) | Large GWAS |
| rs10882398 | — | GWAS association (p=3.0e-09) | Large GWAS |
| rs143439093 | — | GWAS association (p=3.0e-09) | Large GWAS |
| rs4245909 | — | GWAS association (p=3.0e-09) | Large GWAS |
| rs708119 | WNT3A | GWAS association (p=8.0e-09) | Large GWAS |
| rs6224 | FURIN | GWAS association (p=9.0e-09) | Large GWAS |
| rs7862828 | LINC00484 | GWAS association (p=1.0e-08) | Large GWAS |
| rs2442752 | — | GWAS association (p=4.0e-08) | Large GWAS |
| rs17572606 | — | GWAS association (p=5.0e-08) | Large GWAS |
| rs4343 | ACE | Increased preeclampsia risk in pregnancy | Candidate gene study |
| rs234706 | CBS | Increased risk of mild late-onset preeclampsia | Candidate gene study |
| rs1799963 | F2 | Increased risk of preeclampsia | Candidate gene study |
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.