rs2208589

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

diastolic blood pressure

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele A

OR 0.02

p 7.0e-18

N 928,679

Large GWAS

multi-ancestry

preeclampsia

Pujol Gualdo N et al. “Atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses.” Nature Medicine 31(5):1626-1634 (2025)

Allele A

OR 0.85

p 1.0e-10

N 294,039

Large GWAS

European

Honigberg MC et al. “Polygenic prediction of preeclampsia and gestational hypertension.” Nature Medicine 29(6):1540-1549 (2023)

Allele A

OR 1.14

p 3.0e-9

N 193,886

Large GWAS

multi-ancestry

preeclampsia, hypertension, pregnancy-induced

Tyrmi JS et al. “Genetic Risk Factors Associated With Preeclampsia and Hypertensive Disorders of Pregnancy.” Jama Cardiology 8(7):674-683 (2023)

Allele G

OR 1.12

p 2.0e-8

N 130,207

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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