rs259983
▶GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
systolic blood pressure, alcohol drinking
Feitosa MF et al. “Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.” Plos One 13(6):e0198166 (2018)
Allele A
OR —
p 6.0e-21
N 133,355
Large GWAS
multi-ancestry
coronary artery disease
Jordà P et al. “Genetic analyses across cardiovascular traits: leveraging genetic correlations to empower locus discovery and prediction in common cardiovascular diseases.” Npj Genomic Medicine 10(1):65 (2025)
Allele C
OR 8.69
p 4.0e-18
N 310,368
Large GWAS
European
preeclampsia
Honigberg MC et al. “Polygenic prediction of preeclampsia and gestational hypertension.” Nature Medicine 29(6):1540-1549 (2023)
Allele C
OR 1.14
p 1.0e-15
N 455,887
Large GWAS
multi-ancestry
Calcium channel blocker use measurement
Wu Y et al. “Genome-wide association study of medication-use and associated disease in the UK Biobank.” Nature Communications 10(1):1891 (2019)
Allele C
OR 0.08
p 8.0e-12
N 204,378
Major Consortium StudyLarge GWAS
European
preeclampsia, parental genotype effect measurement
Steinthorsdottir V et al. “Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women.” Nature Communications 11(1):5976 (2020)
Allele C
OR 1.17
p 3.0e-10
N 167,234
Large GWAS
multi-ancestry
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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