rs1701704
This is a intron variant variant in the IKZF4 gene.
▶GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
type 1 diabetes mellitus
Plagnol V et al. “Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.” Plos Genetics 7(8):e1002216 (2011)
Allele T
OR 1.25
p 5.0e-18
N 19,102
Large GWAS
European
Hakonarson H et al. “A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study.” Diabetes 57(4):1143-6 (2008)
Allele T
OR 1.25
p 9.0e-10
N 2,171
Large GWAS
European
FEV/FVC ratio
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.02
p 4.0e-15
N 394,642
Large GWAS
European
asthma
Salinas YD et al. “Discovery and Mediation Analysis of Cross-Phenotype Associations Between Asthma and Body Mass Index in 12q13.2.” American Journal of Epidemiology 190(1):85-94 (2021)
Allele G
OR 1.07
p 2.0e-14
N 305,945
Large GWAS
European
Hirota T et al. “Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.” Nature Genetics 43(9):893-6 (2011)
Allele G
OR 1.19
p 2.0e-13
N 4,836
Large GWAS
East Asian
body mass index
Huang J et al. “Genomics and phenomics of body mass index reveals a complex disease network.” Nature Communications 13(1):7973 (2022)
Allele G
OR 0.01
p 2.0e-14
N 1,122,049
Large GWAS
European
smoking initiation
Liu M et al. “Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.” Nature Genetics 51(2):237-244 (2019)
Allele G
OR 0.01
p 4.0e-11
N 931,815
Large GWAS
European
Brazel DM et al. “Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use.” Biological Psychiatry 85(11):946-955 (2019)
Allele G
OR 0.01
p 3.0e-8
N 433,216
Meta-analysisLarge GWAS
European
alopecia areata
Petukhova L et al. “Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.” Nature 466(7302):113-7 (2010)
Allele C
OR 1.34
p 3.0e-8
N 4,332
Large GWAS
European
About IKZF4
Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]
View all IKZF4 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…