rs17104991

This variant is located in the SLC25A21 gene.

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ClinVar annotation

Benign★★★☆
3 submitters2 publications

not provided; Thymoma; Thyroid cancer, nonmedullary, 1; Hepatocellular carcinoma; Nonpapillary renal cell carcinoma; Sarcoma; Uterine carcinosarcoma; Cervical cancer; Uterine corpus endometrial carcinoma; Clear cell carcinoma of kidney; Colon adenocarcinoma; Ovarian serous cystadenocarcinoma

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About SLC25A21

SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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