SLC25A21

solute carrier family 25 member 21

Summary

SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004]

Known Variants101 total

rsidPosition (GRCh37)AllelesClassClinVar
rs1710499114:37,149,866C/A—benign
rs20188746014:37,149,903A/T—uncertain significance
rs74996111014:37,149,904C/T—uncertain significance
rs18788573114:37,149,929A/G—likely benign
rs457543914:37,151,943A/G——
rs75587899614:37,153,048T/C—uncertain significance
rs14953501214:37,153,057G/A—uncertain significance
rs75729242314:37,153,940T/C—likely benign
rs75160778814:37,153,956C/G—uncertain significance
rs77018977414:37,153,972C/A—uncertain significance
rs77807638814:37,153,974T/A—uncertain significance
rs137687509414:37,153,976G/A—uncertain significance
rs250230086014:37,154,001T/A—uncertain significance
rs77486237514:37,154,028G/A—uncertain significance
rs138906850414:37,154,039T/C—pathogenic
rs213914031914:37,154,066A/T—uncertain significance
rs14667849914:37,154,070A/G—uncertain significance
rs76509342714:37,154,076T/C—uncertain significance
rs188246441714:37,154,082C/T—uncertain significance
rs75507513214:37,154,083C/T—likely benign
rs95876795814:37,154,098C/A—likely benign
rs20129951214:37,154,111C/T—likely benign
rs129887181914:37,154,116C/T—likely benign
rs250230186414:37,154,127G/A—uncertain significance
rs14747493714:37,154,145G/T—benign
rs14853071514:37,154,148T/G—benign
rs188385204914:37,180,506A/C—likely benign
rs74617855414:37,180,562G/A—likely benign
rs20096338814:37,180,594G/A—conflicting classifications of pathogenicity
rs14539589014:37,180,615C/T—benign
rs76261033214:37,180,641C/T—likely benign
rs188386369614:37,180,642C/T—uncertain significance
rs188386612514:37,180,668T/A—uncertain significance
rs75753043414:37,180,669A/G—uncertain significance
rs1710508714:37,180,685T/C—benign
rs250238644814:37,180,689T/A—uncertain significance
rs53246625614:37,194,769G/T—uncertain significance
rs250242640314:37,194,773A/C—uncertain significance
rs14017126814:37,194,785G/A—likely benign
rs14649186314:37,194,791C/T—uncertain significance
rs90729692714:37,194,800T/C—uncertain significance
rs52849430114:37,194,805G/A—likely benign
rs77755093614:37,194,855C/G—uncertain significance
rs213921300014:37,194,865T/A—likely benign
rs77200930414:37,194,873T/C—uncertain significance
rs77533862914:37,194,875G/A—uncertain significance
rs20037707014:37,194,876C/T—uncertain significance
rs76666425214:37,194,891A/T—likely benign
rs213921955514:37,198,698A/T—likely benign
rs20054742814:37,198,705C/G—likely benign
rs15042043114:37,198,706A/T—likely benign
rs250243759014:37,198,707C/T—uncertain significance
rs11391642814:37,198,720G/A—uncertain significance
rs19970749214:37,198,726G/A—likely benign
rs76462250814:37,198,727T/C—likely benign
rs75330095714:37,198,734T/C—uncertain significance
rs188473591214:37,198,744A/G—likely benign
rs250243785314:37,198,749T/C—uncertain significance
rs37531256014:37,198,787A/C—likely benign
rs250243813714:37,198,788A/C—likely benign
rs1710515914:37,203,693G/A—benign
rs11492940714:37,203,696C/T—likely benign
rs1013519614:37,203,697G/A—benign
rs104396284614:37,203,714T/C—uncertain significance
rs213922873814:37,203,731G/A—uncertain significance
rs74590368314:37,203,744T/C—uncertain significance
rs117631872414:37,203,749G/A—uncertain significance
rs20068207014:37,203,770C/T—benign
rs225301214:37,228,504C/T—benign
rs84812514:37,247,812T/A——
rs84808714:37,277,643A/Gupstream gene variant—
rs163193314:37,278,964A/Gdownstream gene variant—
rs277403514:37,279,147A/C——
rs250267998414:37,283,104A/T—likely benign
rs77029433414:37,283,110A/G—likely benign
rs14167799314:37,283,123C/A—uncertain significance
rs141867469514:37,283,128C/T—uncertain significance
rs14703553614:37,283,144C/T—likely benign
rs14809780114:37,283,145G/A—uncertain significance
rs75155025514:37,283,152G/A—likely benign
rs19184500614:37,283,158C/G—uncertain significance
rs11813031214:37,283,181C/T—likely benign
rs37274992814:37,283,184T/C—uncertain significance
rs37309680214:37,283,191T/C—likely benign
rs75290724514:37,344,150C/T—likely benign
rs75652389914:37,344,155C/A—uncertain significance
rs11599449614:37,344,183G/A—benign
rs13887323814:37,344,204C/A—likely benign
rs1710559114:37,344,229A/G—likely benign
rs802324814:37,402,131C/T——
rs2848798914:37,458,034T/Cregulatory region variant—
rs980603714:37,489,008A/G—benign
rs74646864714:37,641,471G/A—likely benign
rs100192848414:37,641,477T/C—likely benign
rs20003584814:37,641,494C/G—likely benign
rs53245599514:37,641,504C/A—conflicting classifications of pathogenicity
rs77556992614:37,641,505G/C—uncertain significance
rs119308338314:37,641,518G/A—uncertain significance
rs138122894014:37,641,537C/T—uncertain significance
rs76228664614:37,641,541A/G—likely benign

Showing 100 of 101 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.