rs28487989
This is a regulatory region variant variant in the SLC25A21 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Back pain
Bjornsdottir G et al. “Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology.” Nature Communications 13(1):634 (2022)
Allele C
OR 0.95
p 3.0e-12
N 981,812
Large GWAS
European
About SLC25A21
SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004]
View all SLC25A21 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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