rs4575439

This variant is located in the SLC25A21 gene.

▶

GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

estrogen-receptor positive breast cancer

Jia G et al. “Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction.” Nature Genetics 56(5):819-826 (2024)

Allele G

OR 1.12

p 1.0e-8

N 28,328

Large GWAS

African American or Afro-Caribbean, Sub-Saharan African, African unspecified

About SLC25A21

SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004]

View all SLC25A21 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Loading comments…