rs17207986

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

ulcerative colitis

Talin Haritunians et al. “Genetic predictors of medically refractory ulcerative colitis” Inflammatory Bowel Diseases (2010)
Allele G
OR 3.95
p 1.0e-16
N 3,462
Large GWAS
European

body height

Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)
Allele C
OR 0.01
p 3.0e-10
N 5,314,291
Large GWAS
European, Hispanic or Latin American, East Asian, African unspecified, South Asian
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Research that mentions this SNP (1)

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Genetic predictors of medically refractory ulcerative colitis
AssociationN=861Talin Haritunians et al.(2010)· Inflammatory Bowel Diseases

Genome-wide association study identifying 46 SNPs associated with medically refractory ulcerative colitis (MR-UC) that together explain 48% of the variance in colectomy risk. A genetic risk score based on these SNPs achieved an AUC of 0.91 in predicting colectomy need, with risk categories showing 0-100% colectomy rates. Genome-wide significant associations were confirmed at the MHC region (rs17207986, p=1.4×10^-16) and suggestive association at TNFSF15/TL1A (rs11554257, p=1.4×10^-6).

Traits studied:Colectomy riskExtensive diseaseMedically refractory ulcerative colitisUlcerative colitis severity
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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