rs17287293

This is a intergenic variant variant in the LOC105369698 gene.

▶

GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

PR interval

van Setten J et al. “PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.” Nature Communications 9(1):2904 (2018)
Allele G
OR 2.20
p 2.0e-41
N 92,340
Meta-analysisLarge GWAS
European

heart rate

den Hoed M et al. “Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.” Nature Genetics 45(6):621-31 (2013)
Allele A
OR 0.44
p 3.0e-20
N 92,355
Large GWAS
multi-ancestry
Eijgelsheim M et al. “Genome-wide association analysis identifies multiple loci related to resting heart rate.” Human Molecular Genetics 19(19):3885-94 (2010)
Allele A
OR 8.60
p 2.0e-10
N 38,991
Large GWAS
European

pulse pressure measurement

Surendran P et al. “Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.” Nature Genetics 52(12):1314-1332 (2020)
Allele A
OR 0.20
p 3.0e-14
N 810,865
Meta-analysisLarge GWAS
European
Evangelou E et al. “Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.” Nature Genetics 50(10):1412-1425 (2018)
Allele A
OR 0.20
p 6.0e-12
N 757,601
Large GWAS
European

diastolic blood pressure

Surendran P et al. “Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.” Nature Genetics 52(12):1314-1332 (2020)
Allele A
OR 0.14
p 7.0e-10
N 810,865
Meta-analysisLarge GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…