rs17382202

This is a intron variant variant in the PDE4D gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

response to quetiapine

Clark SL et al. “Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment.” Pharmacogenetics and Genomics 23(2):69-77 (2013)

Allele T

OR —

p 4.0e-8

N 738

Small GWAS

multi-ancestry

About PDE4D

This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]

View all PDE4D variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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