PDE4D
phosphodiesterase 4D
Summary
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
Known Variants476 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs886060700 | 5:58,264,946 | G/T | — | uncertain significance |
| rs538935097 | 5:58,265,078 | C/G | — | uncertain significance |
| rs142429682 | 5:58,265,187 | G/A | — | benign |
| rs143961299 | 5:58,265,196 | C/A | — | uncertain significance |
| rs866638632 | 5:58,265,208 | T/C | — | uncertain significance |
| rs11950492 | 5:58,265,231 | A/G | — | benign |
| rs11950495 | 5:58,265,250 | A/G | — | benign |
| rs1742226834 | 5:58,265,290 | C/T | — | uncertain significance |
| rs886060701 | 5:58,265,301 | T/C | — | uncertain significance |
| rs829257 | 5:58,265,366 | G/A | — | benign |
| rs11959349 | 5:58,265,373 | A/C | — | benign |
| rs886060702 | 5:58,265,491 | T/C | — | uncertain significance |
| rs1024653706 | 5:58,265,510 | G/C | — | uncertain significance |
| rs11956001 | 5:58,265,526 | C/A | — | benign |
| rs13160982 | 5:58,265,576 | G/A | — | benign |
| rs17291089 | 5:58,265,605 | T/G | — | uncertain significance |
| rs1742320588 | 5:58,265,764 | G/C | — | uncertain significance |
| rs186917544 | 5:58,265,788 | T/C | — | uncertain significance |
| rs536451907 | 5:58,265,816 | C/T | — | likely benign |
| rs79996648 | 5:58,265,831 | G/A | — | benign |
| rs75820400 | 5:58,265,832 | A/C | — | benign |
| rs532407753 | 5:58,265,869 | C/A | — | benign |
| rs1742363826 | 5:58,265,962 | G/A | — | uncertain significance |
| rs1742364726 | 5:58,265,967 | G/A | — | uncertain significance |
| rs886060703 | 5:58,265,978 | G/A | — | uncertain significance |
| rs74874819 | 5:58,266,093 | A/C | — | benign |
| rs10071088 | 5:58,266,452 | C/A | — | benign |
| rs829258 | 5:58,266,490 | C/G | — | benign |
| rs1046069326 | 5:58,266,599 | C/T | — | uncertain significance |
| rs886060704 | 5:58,266,616 | C/T | — | uncertain significance |
| rs866405146 | 5:58,266,628 | A/G | — | uncertain significance |
| rs886060705 | 5:58,266,647 | C/T | — | uncertain significance |
| rs547764520 | 5:58,266,903 | T/G | — | benign |
| rs886060706 | 5:58,266,929 | A/G | — | uncertain significance |
| rs949531257 | 5:58,266,999 | A/C | — | uncertain significance |
| rs1466070150 | 5:58,267,073 | A/G | — | uncertain significance |
| rs72764043 | 5:58,267,142 | A/T | — | benign |
| rs1742565588 | 5:58,267,166 | A/G | — | uncertain significance |
| rs188938118 | 5:58,267,277 | A/T | — | benign |
| rs1742583103 | 5:58,267,281 | T/C | — | uncertain significance |
| rs1742609985 | 5:58,267,463 | T/C | — | uncertain significance |
| rs200919800 | 5:58,267,492 | A/G | — | uncertain significance |
| rs702530 | 5:58,267,557 | C/T | — | benign |
| rs1038876803 | 5:58,267,650 | T/G | — | uncertain significance |
| rs702531 | 5:58,267,723 | A/C | — | benign |
| rs557226166 | 5:58,267,744 | C/T | — | conflicting classifications of pathogenicity |
| rs13172038 | 5:58,267,838 | G/A | — | uncertain significance |
| rs542930751 | 5:58,267,887 | T/G | — | uncertain significance |
| rs829259 | 5:58,267,976 | A/T | — | benign |
| rs576580458 | 5:58,267,981 | G/A | — | benign |
| rs10035437 | 5:58,268,007 | A/G | — | benign |
| rs185766952 | 5:58,268,108 | C/T | — | uncertain significance |
| rs796829320 | 5:58,268,122 | C/T | — | uncertain significance |
| rs548172452 | 5:58,268,155 | A/C | — | benign |
| rs74710642 | 5:58,268,162 | C/T | — | benign |
| rs10036063 | 5:58,268,203 | T/C | — | benign |
| rs12658211 | 5:58,268,212 | C/A | — | benign |
| rs1742779838 | 5:58,268,266 | G/A | — | uncertain significance |
| rs1742783371 | 5:58,268,293 | G/A | — | uncertain significance |
| rs1742786887 | 5:58,268,306 | A/C | — | uncertain significance |
| rs577109679 | 5:58,268,391 | G/A | — | conflicting classifications of pathogenicity |
| rs73758090 | 5:58,268,425 | A/G | — | benign |
| rs760686759 | 5:58,268,487 | G/T | — | uncertain significance |
| rs577458431 | 5:58,268,488 | A/G | — | uncertain significance |
| rs10940636 | 5:58,268,553 | G/A | — | benign |
| rs749539498 | 5:58,268,567 | A/G | — | uncertain significance |
| rs77207456 | 5:58,268,641 | A/G | — | benign |
| rs1580002684 | 5:58,268,713 | A/G | — | uncertain significance |
| rs829260 | 5:58,268,718 | T/C | — | benign |
| rs751797196 | 5:58,268,762 | C/G | — | uncertain significance |
| rs530824932 | 5:58,268,842 | G/A | — | uncertain significance |
| rs10075508 | 5:58,268,853 | C/T | — | benign |
| rs190993206 | 5:58,268,854 | G/A | — | benign |
| rs961856114 | 5:58,268,919 | T/C | — | uncertain significance |
| rs886060707 | 5:58,269,045 | A/G | — | uncertain significance |
| rs886060708 | 5:58,269,112 | T/C | — | uncertain significance |
| rs187518449 | 5:58,269,130 | G/A | — | benign |
| rs149834563 | 5:58,269,168 | T/A | — | benign |
| rs556877242 | 5:58,269,196 | C/T | — | uncertain significance |
| rs775984561 | 5:58,269,213 | G/A | — | uncertain significance |
| rs886060709 | 5:58,269,223 | A/G | — | uncertain significance |
| rs17719258 | 5:58,269,240 | T/C | — | benign |
| rs559220819 | 5:58,269,290 | T/A | — | likely benign |
| rs577495801 | 5:58,269,291 | A/T | — | likely benign |
| rs886060710 | 5:58,269,457 | G/A | — | uncertain significance |
| rs369129936 | 5:58,269,660 | T/G | — | benign |
| rs886060712 | 5:58,269,711 | C/G | — | uncertain significance |
| rs886060713 | 5:58,269,842 | A/C | — | uncertain significance |
| rs781074391 | 5:58,269,956 | T/C | — | uncertain significance |
| rs140371223 | 5:58,270,025 | C/A | — | benign |
| rs886060715 | 5:58,270,070 | T/C | — | uncertain significance |
| rs1030455444 | 5:58,270,077 | A/G | — | uncertain significance |
| rs752738157 | 5:58,270,088 | C/T | — | uncertain significance |
| rs558677290 | 5:58,270,181 | G/T | — | uncertain significance |
| rs953481477 | 5:58,270,360 | A/G | — | uncertain significance |
| rs963578789 | 5:58,270,433 | C/T | — | uncertain significance |
| rs7736186 | 5:58,270,494 | T/C | — | likely benign |
| rs753989811 | 5:58,270,495 | G/A | — | uncertain significance |
| rs775821294 | 5:58,270,507 | C/T | — | likely benign |
| rs201517515 | 5:58,270,517 | T/C | — | likely benign |
Showing 100 of 476 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.