rs17444059

This is a regulatory region variant variant in the PDE4D gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

response to vaccine, cytokine measurement

Kennedy RB et al. “Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients” Human Genetics (2012)

Allele G

OR —

p 2.0e-8

N 711

Small GWAS

multi-ancestry

About PDE4D

This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]

View all PDE4D variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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