rs17483466

This is a intron variant variant in the ACOXL gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

chronic lymphocytic leukemia

Berndt SI et al. “Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.” Nature Genetics 45(8):868-76 (2013)

Allele G

OR 1.37

p 4.0e-17

N 8,400

Large GWAS

European

Di Bernardo MC et al. “A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.” Nature Genetics 40(10):1204-10 (2008)

Allele G

OR 1.39

p 2.0e-10

N 1,943

Large GWAS

European

About ACOXL

Predicted to enable acyl-CoA oxidase activity; fatty acid binding activity; and flavin adenine dinucleotide binding activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA oxidase. Predicted to be located in peroxisomal matrix. Predicted to be active in peroxisome. [provided by Alliance of Genome Resources, Jul 2025]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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