rs17496249

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

PR interval

Ntalla I et al. “Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction.” Nature Communications 11(1):2542 (2020)
Allele A
OR 0.64
p 1.0e-23
N 292,566
Large GWAS
multi-ancestry

triglyceride measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele G
OR 0.01
p 2.0e-13
N 455,659
Large GWAS
multi-ancestry
Koskeridis F et al. “Pleiotropic genetic architecture and novel loci for C-reactive protein levels.” Nature Communications 13(1):6939 (2022)
Allele G
OR 0.01
p 1.0e-8
N 361,194
Large GWAS
European

appendicular lean mass

Pei YF et al. “The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study.” Communications Biology 3(1):608 (2020)
Allele A
OR 0.01
p 7.0e-11
N 450,243
Major Consortium StudyLarge GWAS
European

amygdala volume

Mufford MS et al. “The Genetic Architecture of Amygdala Nuclei.” Biological Psychiatry 95(1):72-84 (2024)
Allele G
OR 0.21
p 1.0e-9
N 36,352
Large GWAS
multi-ancestry
Ji Y et al. “Cross-ancestry and sex-stratified genome-wide association analyses of amygdala and subnucleus volumes.” Nature Genetics 57(4):839-850 (2025)
Allele G
OR 0.03
p 8.0e-9
N 35,474
Large GWAS
European

neuroimaging measurement

Bhatt RR et al. “The Genetic Architecture of the Human Corpus Callosum and its Subregions.” Nature Communications 16(1):9708 (2025)
Allele A
OR 0.03
p 6.0e-9
N 46,685
Large GWAS
European

cortical thickness

Zhukovsky P et al. “Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression.” Nature Communications 15(1):5207 (2024)
Allele A
OR —
p 8.0e-9
N 34,553
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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