rs17576323

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

aspartate aminotransferase measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.02
p 6.0e-13
N 394,642
Large GWAS
European
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele C
OR 0.02
p 2.0e-9
N 493,058
Large GWAS
multi-ancestry

BMI-adjusted waist circumference

Christakoudi S et al. “GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer.” Scientific Reports 11(1):10688 (2021)
Allele C
OR 0.03
p 9.0e-13
N 219,872
Major Consortium StudyLarge GWAS
European

high density lipoprotein cholesterol measurement

Hoffmann TJ et al. “A large electronic-health-record-based genome-wide study of serum lipids.” Nature Genetics 50(3):401-413 (2018)
Allele T
OR —
β 0.021
p 3.0e-9
N 283,251
Large GWAS
multi-ancestry

white matter hyperintensity measurement

Zhukovsky P et al. “Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression.” Nature Communications 15(1):5207 (2024)
Allele C
OR 5.86
p 5.0e-9
N 30,708
Large GWAS
European
Persyn E et al. “Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants.” Nature Communications 11(1):2175 (2020)
Allele C
OR 5.35
p 3.0e-8
N 45,204
Large GWAS
multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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