rs17593068
This is a regulatory region variant variant in the GSTP1 gene.
▶ClinVar annotation
▶Research that mentions this SNP (1)
▶Xenobiotic‐Metabolizing gene polymorphisms and ovarian cancer riskAssociationN=3,617Ellen L. Goode et al.(2011)· Molecular Carcinogenesis
A case-control study of 1,571 ovarian cancer cases and 2,046 controls found associations between xenobiotic-metabolizing gene polymorphisms and ovarian cancer risk. EPHX1 rs1051740 was associated with increased serous ovarian cancer risk (OR 1.17, p = 0.01), ADH4 rs1042364 with decreased ovarian cancer risk (OR 0.90, p = 0.05), and NQO1 rs2917666 with increased ovarian cancer risk (OR 1.11, p = 0.04).
About GSTP1
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]
View all GSTP1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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