GSTP1
glutathione S-transferase pi 1
Pharmacogene
Summary
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]
Known Variants27 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs6591255 | 11:67,349,548 | T/A | upstream gene variant | — |
| rs6591256 | 11:67,349,899 | A/G | upstream gene variant | — |
| rs11227840 | 11:67,350,788 | C/A | — | benign |
| rs11227841 | 11:67,350,790 | C/T | — | benign |
| rs17593068 | 11:67,350,932 | G/T | regulatory region variant | benign |
| rs36211088 | 11:67,350,999 | A/C | — | benign |
| rs36211089 | 11:67,351,004 | C/T | — | benign |
| rs8191439 | 11:67,351,297 | G/A | regulatory region variant | benign |
| rs1079719 | 11:67,351,531 | G/A | — | benign |
| rs1871041 | 11:67,351,540 | A/G | — | benign |
| rs4147581 | 11:67,351,585 | C/G | regulatory region variant | benign |
| rs2370143 | 11:67,351,774 | C/T | — | benign |
| rs1354173738 | 11:67,351,952 | C/G | — | uncertain significance |
| rs8191448 | 11:67,352,161 | C/T | — | benign |
| rs373014884 | 11:67,352,208 | C/A | — | uncertain significance |
| rs762803 | 11:67,352,256 | C/A | regulatory region variant | benign |
| rs1695 | 11:67,352,689 | A/G | missense variant | benign |
| rs749174 | 11:67,353,253 | G/A | intron variant | benign |
| rs1138272 | 11:67,353,579 | C/T | missense variant | association |
| rs1871042 | 11:67,353,844 | C/T | regulatory region variant | benign |
| rs762120399 | 11:67,353,869 | G/A | — | uncertain significance |
| rs201449696 | 11:67,353,899 | A/C | — | uncertain significance |
| rs567508164 | 11:67,353,934 | G/A | — | likely benign |
| rs768896121 | 11:67,353,935 | T/A | — | uncertain significance |
| rs4891 | 11:67,353,970 | T/C | synonymous variant | benign |
| rs947895 | 11:67,354,406 | C/T | — | — |
| rs8191452 | 11:67,354,435 | T/G | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.