rs4891

This is a synonymous variant in the GSTP1 gene — it does not change the protein's amino acid sequence.

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ClinVar annotation

Benign★★★☆
2 submitters1 publication
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Research that mentions this SNP (1)

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Genetic polymorphisms ofMPO,GSTT1,GSTM1,GSTP1,EPHX1andNQO1as risk factors of early‐onset lung cancer
AssociationN=1,938Maria Timofeeva et al.(2010)· International Journal of Cancer

Case-control study (638 early-onset lung cancer cases, 1,300 controls) examining 17 SNPs and 2 deletion polymorphisms across MPO, GSTT1, GSTM1, GSTP1, EPHX1, and NQO1 genes. No significant overall associations with early-onset lung cancer risk; subgroup analyses revealed gender- and/or smoking-specific effects for EPHX1 (rs2854455, rs2234922), GSTP1 (rs1695, rs947895, rs4891), GSTT1, and NQO1 (rs1800566), but none survived Bonferroni correction.

Traits studied:Early-onset lung cancer
PubMedDOIMetascience Observatory

About GSTP1

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]

View all GSTP1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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