Trait
SNPs associated with Lung cancer
48 genetic variants across 17 genes have been associated with Lung cancer in published research. Key genes include BRCA2, CASC8, CHEK2.
Associated variants48 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs16969968 | CHRNA5 | Increased lung cancer risk | Meta-analysis |
| rs2736100 | TERT | Higher lung cancer risk | Meta-analysis |
| rs1801394 | MTRR | Increased lung cancer susceptibility | Meta-analysis |
| rs1042522 | TP53 | Increased lung cancer susceptibility | Meta-analysis |
| rs1695 | GSTP1 | Increased lung cancer risk in Asian populations | Meta-analysis |
| rs8042849 | — | GWAS association (p=4.0e-15) | Major Consortium Study |
| rs2036527 | — | GWAS association (p=8.0e-179) | Large GWAS |
| rs421284 | — | GWAS association (p=2.0e-58) | Large GWAS |
| rs7726159 | TERT | Increased lung cancer risk | Large GWAS |
| rs56113850 | CYP2A6 | GWAS association (p=1.0e-43) | Large GWAS |
| rs31490 | CLPTM1L | GWAS association (p=8.0e-40) | Large GWAS |
| rs3131856 | — | GWAS association (p=2.0e-27) | Large GWAS |
| rs7705526 | TERT | GWAS association (p=2.0e-23) | Large GWAS |
| rs9267123 | — | GWAS association (p=3.0e-23) | Large GWAS |
| rs11571815 | BRCA2 | GWAS association (p=1.0e-21) | Large GWAS |
| rs11571833 | BRCA2 | GWAS association (p=1.0e-20) | Large GWAS |
| rs113623975 | — | GWAS association (p=3.0e-19) | Large GWAS |
| rs12914385 | CHRNA3 | GWAS association (p=1.0e-18) | Large GWAS |
| rs77468143 | — | GWAS association (p=9.0e-18) | Large GWAS |
| rs17486278 | CHRNA5 | GWAS association (p=2.0e-17) | Large GWAS |
| rs112401627 | — | GWAS association (p=9.0e-17) | Large GWAS |
| rs71658797 | — | GWAS association (p=2.0e-16) | Large GWAS |
| rs13036436 | CHRNA4 | GWAS association (p=9.0e-16) | Large GWAS |
| rs7953330 | — | GWAS association (p=1.0e-15) | Large GWAS |
| rs11778371 | — | GWAS association (p=3.0e-15) | Large GWAS |
| rs2853677 | TERT | GWAS association (p=5.0e-15) | Large GWAS |
| rs7868253 | — | GWAS association (p=1.0e-14) | Large GWAS |
| rs11634901 | SECISBP2L | GWAS association (p=1.0e-14) | Large GWAS |
| rs1056562 | — | GWAS association (p=1.0e-13) | Large GWAS |
| rs398278 | LOC105378120 | GWAS association (p=1.0e-13) | Large GWAS |
| rs17879961 | CHEK2 | GWAS association (p=6.0e-13) | Large GWAS |
| rs1629083 | — | GWAS association (p=8.0e-12) | Large GWAS |
| rs4946256 | — | GWAS association (p=3.0e-11) | Large GWAS |
| rs77045810 | — | GWAS association (p=3.0e-11) | Large GWAS |
| rs239935 | — | GWAS association (p=4.0e-11) | Large GWAS |
| rs12265047 | — | GWAS association (p=2.0e-10) | Large GWAS |
| rs1124241 | — | GWAS association (p=3.0e-10) | Large GWAS |
| rs7300571 | — | GWAS association (p=6.0e-10) | Large GWAS |
| rs9920763 | TP53BP1 | GWAS association (p=7.0e-10) | Large GWAS |
| rs75675343 | LOC105377262 | GWAS association (p=8.0e-10) | Large GWAS |
| rs216859 | — | GWAS association (p=3.0e-09) | Large GWAS |
| rs4488809 | TP63 | GWAS association (p=4.0e-09) | Large GWAS |
| rs329122 | — | GWAS association (p=4.0e-09) | Large GWAS |
| rs144437384 | CYP2A6 | GWAS association (p=5.0e-09) | Large GWAS |
| rs11878604 | — | GWAS association (p=2.0e-08) | Large GWAS |
| rs11639372 | — | GWAS association (p=3.0e-08) | Large GWAS |
| rs144840030 | — | GWAS association (p=4.0e-08) | Large GWAS |
| rs6983267 | CASC8 | Higher lung cancer risk | Preliminary work |
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.