rs421284
▶GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
basal cell carcinoma
Choquet H et al. “Multi-ancestry genome-wide meta-analysis identifies novel basal cell carcinoma loci and shared genetic effects with squamous cell carcinoma.” Communications Biology 7(1):33 (2024)
Allele C
OR 0.86
p 4.0e-77
N 812,765
Meta-analysisLarge GWAS
multi-ancestry
Liyanage UE et al. “Combined analysis of keratinocyte cancers identifies novel genome-wide loci.” Human Molecular Genetics 28(18):3148-3160 (2019)
Allele C
OR 1.14
p 8.0e-56
N 651,138
Large GWAS
European
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.17
p 7.0e-17
N 394,626
Large GWAS
European
Chahal HS et al. “Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma.” Nature Communications 7:12510 (2016)
Allele C
OR 1.11
p 1.0e-18
N 275,209
Large GWAS
European
lung cancer
Gorman BR et al. “Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk.” Nature Communications 15(1):8629 (2024)
Allele T
OR 1.13
p 2.0e-58
N 223,372
Large GWAS
multi-ancestry
keratinocyte carcinoma
Liyanage UE et al. “Combined analysis of keratinocyte cancers identifies novel genome-wide loci.” Human Molecular Genetics 28(18):3148-3160 (2019)
Allele T
OR 1.13
p 6.0e-46
N 358,840
Large GWAS
European
sebaceous gland disease
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.07
p 2.0e-39
N 565,662
Major Consortium StudyLarge GWAS
multi-ancestry
Uveal Melanoma
Mies G et al. “Meta-analysis of uveal melanoma genome-wide association studies identifies novel risk loci and population effect size heterogeneity.” Hgg Advances 6(3):100465 (2025)
Allele T
OR —
p 8.0e-11
N 354,387
Meta-analysisLarge GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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