rs7953330

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

lung cancer, family history of lung cancer

Gabriel AAG et al. “Genetic Analysis of Lung Cancer and the Germline Impact on Somatic Mutation Burden.” Journal of the National Cancer Institute 114(8):1159-1166 (2022)
Allele C
OR 0.92
p 1.0e-18
N 329,946
Large GWAS
European

squamous cell lung carcinoma

Gorman BR et al. “Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk.” Nature Communications 15(1):8629 (2024)
Allele C
OR 0.88
p 8.0e-18
N 135,790
Large GWAS
multi-ancestry
McKay JD et al. “Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.” Nature Genetics 49(7):1126-1132 (2017)
Allele C
OR 1.16
p 7.0e-13
N 63,053
Large GWAS
European

lung cancer

Gorman BR et al. “Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk.” Nature Communications 15(1):8629 (2024)
Allele C
OR 0.94
p 1.0e-15
N 223,372
Large GWAS
multi-ancestry

upper aerodigestive tract neoplasm

Lesseur C et al. “Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers.” Plos Genetics 17(3):e1009254 (2021)
Allele C
OR 0.89
p 2.0e-13
N 75,848
Meta-analysisLarge GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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