rs11878604
▶GWAS Catalog Trait Associations (10)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (10)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
smoking cessation
Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)
Allele C
OR 0.03
p 4.0e-51
N 1,400,535
Large GWAS
European, East Asian, Hispanic or Latin American, African unspecified
alkaline phosphatase measurement
Chen VL et al. “Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology.” Nature Communications 12(1):816 (2021)
Allele C
OR 11.20
p 2.0e-29
N 390,964
Large GWAS
multi-ancestry
serum alanine aminotransferase amount
Kim YJ et al. “The contribution of common and rare genetic variants to variation in metabolic traits in 288,137 East Asians.” Nature Communications 13(1):6642 (2022)
Allele C
OR 0.03
p 2.0e-28
N 288,127
Large GWAS
East Asian
Chen VL et al. “Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology.” Nature Communications 12(1):816 (2021)
Allele C
OR 8.39
p 5.0e-17
N 390,812
Large GWAS
multi-ancestry
nicotine metabolite ratio
Patel YM et al. “Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk.” Cancer Research 76(19):5768-5776 (2016)
Allele C
OR 0.28
p 7.0e-24
N 2,239
Large GWAS
multi-ancestry
cigarettes per day measurement
Koskeridis F et al. “Pleiotropic genetic architecture and novel loci for C-reactive protein levels.” Nature Communications 13(1):6939 (2022)
Allele T
OR 0.04
p 8.0e-23
N 337,334
Large GWAS
European
aspartate aminotransferase measurement
Kim YJ et al. “The contribution of common and rare genetic variants to variation in metabolic traits in 288,137 East Asians.” Nature Communications 13(1):6642 (2022)
Allele C
OR 0.02
p 1.0e-16
N 288,127
Large GWAS
East Asian
lung carcinoma
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele C
OR 0.15
p 1.0e-13
N 671,529
Large GWAS
multi-ancestry
chronic obstructive pulmonary disease
Ishigaki K et al. “Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases.” Nature Genetics 52(7):669-679 (2020)
Allele C
OR 0.84
p 6.0e-12
N 204,907
Large GWAS
East Asian
high density lipoprotein cholesterol measurement
Richardson TG et al. “Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.” Plos Medicine 17(3):e1003062 (2020)
Allele T
OR 0.02
p 3.0e-9
N 403,943
Large GWAS
European
lung cancer
Sato G et al. “Pan-cancer and cross-population genome-wide association studies dissect shared genetic backgrounds underlying carcinogenesis.” Nature Communications 14(1):3671 (2023)
Allele C
OR 0.87
p 2.0e-8
N 153,948
Large GWAS
East Asian
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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