rs8042849

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GWAS Catalog Trait Associations (9)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

smoking behavior trait

Wootton RE et al. “Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation study.” Psychological Medicine 50(14):2435-2443 (2020)
Allele C
OR 0.03
p 2.0e-39
N 462,690
Large GWAS
European

parental longevity

Timmers PR et al. “Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances.” Elife 8 (2019)
Allele T
OR 0.44
p 2.0e-26
N 500,193
Large GWAS
European
Joshi PK et al. “Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity.” Nature Communications 8(1):910 (2017)
Allele T
OR 0.40
p 4.0e-14
N 606,059
Meta-analysisLarge GWAS
multi-ancestry

healthspan, parental longevity, life span determination trait

Timmers PRHJ et al. “Multivariate genomic scan implicates novel loci and haem metabolism in human ageing.” Nature Communications 11(1):3570 (2020)
Allele T
OR —
p 1.0e-24
N 837,415
Large GWAS
European

forced expiratory volume, 25-hydroxyvitamin D3 measurement

Seo J et al. “Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function.” The American Journal of Clinical Nutrition 119(5):1227-1237 (2024)
Allele C
OR —
p 4.0e-21
N 95,952
Meta-analysisLarge GWAS
multi-ancestry

lung cancer

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.18
p 4.0e-15
N 371,173
Major Consortium StudyLarge GWAS
multi-ancestry

aging

Rosoff DB et al. “Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging.” Nature Aging 3(8):1020-1035 (2023)
Allele C
OR 0.01
p 1.0e-12
N 1,559,001
Large GWAS
European

lung carcinoma

Rashkin SR et al. “Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts.” Nature Communications 11(1):4423 (2020)
Allele C
OR 1.20
p 8.0e-10
N 412,835
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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