rs329122

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GWAS Catalog Trait Associations (8)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

smoking initiation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)

Allele A

OR 0.01

p 1.0e-31

N 3,382,012

Large GWAS

European, East Asian, Hispanic or Latin American, African unspecified

type 2 diabetes mellitus

Suzuki K et al. “Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.” Nature 627(8003):347-357 (2024)

Allele A

OR —

p 4.0e-24

N 2,535,601

Large GWAS

multi-ancestry

Elashi AA et al. “Genome-wide association study and trans-ethnic meta-analysis identify novel susceptibility loci for type 2 diabetes mellitus.” Bmc Medical Genomics 17(1):115 (2024)

Allele A

OR 0.04

p 4.0e-16

N 6,710,881

Meta-analysisLarge GWAS

multi-ancestry

Vujkovic M et al. “Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis.” Nature Genetics 52(7):680-691 (2020)

Allele A

OR 0.03

p 1.0e-8

N 1,114,458

Meta-analysisLarge GWAS

European

Mahajan A et al. “Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.” Nature Genetics 50(11):1505-1513 (2018)

Allele A

OR 1.04

p 4.0e-9

N 898,130

Large GWAS

European

Spracklen CN et al. “Identification of type 2 diabetes loci in 433,540 East Asian individuals.” Nature 582(7811):240-245 (2020)

Allele A

OR 1.04

p 2.0e-8

N 433,540

Large GWAS

East Asian

Huerta-Chagoya A et al. “Rare variant analyses in 51,256 type 2 diabetes cases and 370,487 controls reveal the pathogenicity spectrum of monogenic diabetes genes.” Nature Genetics 56(11):2370-2379 (2024)

Allele A

OR 0.06

p 9.0e-13

N 421,743

Large GWAS

multi-ancestry

Mahajan A et al. “Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.” Nature Genetics 54(5):560-572 (2022)

Allele A

OR 0.04

p 2.0e-8

N 251,740

Large GWAS

European

Zhao W et al. “Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.” Nature Genetics 49(10):1450-1457 (2017)

Allele A

OR 1.04

p 3.0e-9

N 183,651

Large GWAS

multi-ancestry

body weight

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele A

OR 0.01

p 4.0e-22

N 928,679

Large GWAS

multi-ancestry

body mass index

Huang J et al. “Genomics and phenomics of body mass index reveals a complex disease network.” Nature Communications 13(1):7973 (2022)

Allele G

OR 0.01

p 3.0e-16

N 1,122,049

Large GWAS

European

Koskeridis F et al. “Pleiotropic genetic architecture and novel loci for C-reactive protein levels.” Nature Communications 13(1):6939 (2022)

Allele G

OR 0.01

p 6.0e-16

N 694,649

Large GWAS

European

Sidorenko J et al. “Genetic architecture reconciles linkage and association studies of complex traits.” Nature Genetics 56(11):2352-2360 (2024)

Allele G

OR 0.01

p 3.0e-13

N 650,000

Large GWAS

European

sex hormone-binding globulin measurement

Ruth KS et al. “Using human genetics to understand the disease impacts of testosterone in men and women.” Nature Medicine 26(2):252-258 (2020)

Allele G

OR 0.01

p 2.0e-14

N 180,094

Large GWAS

European

JT interval

Young WJ et al. “Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.” Nature Communications 13(1):5144 (2022)

Allele A

OR 0.02

p 3.0e-10

N 212,199

Large GWAS

European

testosterone measurement

Ruth KS et al. “Using human genetics to understand the disease impacts of testosterone in men and women.” Nature Medicine 26(2):252-258 (2020)

Allele G

OR 0.02

p 3.0e-9

N 194,453

Large GWAS

European

Venkatesh SS et al. “Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum.” Nature Genetics 57(5):1107-1118 (2025)

Allele G

OR 0.01

p 2.0e-8

N 235,096

Large GWAS

European

lung cancer

Gorman BR et al. “Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk.” Nature Communications 15(1):8629 (2024)

Allele A

OR 0.95

p 4.0e-9

N 223,372

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

rs329122

GWAS Catalog Trait Associations (8)

smoking initiation

type 2 diabetes mellitus

body weight

body mass index

sex hormone-binding globulin measurement

JT interval

testosterone measurement

lung cancer

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