rs1768510774

This variant is located in the GLP1R gene.

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ClinVar annotation

Uncertain Significance★☆☆☆

1 submitter

not specified

About GLP1R

This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

View all GLP1R variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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