GLP1R
glucagon like peptide 1 receptor
Summary
This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
Known Variants35 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs200721844 | 6:39,016,630 | C/T | — | uncertain significance |
| rs10305420 | 6:39,016,636 | C/T | missense variant | — |
| rs1768022624 | 6:39,016,648 | C/A | — | uncertain significance |
| rs5875652 | 6:39,019,672 | G/T | — | — |
| rs201675748 | 6:39,024,224 | C/T | — | uncertain significance |
| rs2295006 | 6:39,024,225 | G/A | — | benign |
| rs201231115 | 6:39,024,231 | G/A | — | uncertain significance |
| rs10305437 | 6:39,024,238 | C/G | — | benign |
| rs10305444 | 6:39,025,309 | G/A | — | benign |
| rs753705639 | 6:39,025,313 | G/A | — | uncertain significance |
| rs2480885708 | 6:39,025,319 | G/A | — | uncertain significance |
| rs144122530 | 6:39,033,500 | C/T | — | benign |
| rs146487412 | 6:39,033,530 | C/T | — | benign |
| rs1768488422 | 6:39,033,567 | G/T | — | uncertain significance |
| rs3765467 | 6:39,033,595 | G/C | missense variant | — |
| rs199790397 | 6:39,034,011 | C/G | — | uncertain significance |
| rs1768510774 | 6:39,034,040 | C/T | — | uncertain significance |
| rs61754624 | 6:39,034,071 | C/T | — | likely benign |
| rs6923761 | 6:39,034,072 | G/C | missense variant | — |
| rs9380826 | 6:39,037,662 | G/C | intron variant | — |
| rs9394574 | 6:39,039,140 | A/G | — | — |
| rs9296285 | 6:39,040,469 | A/G | intron variant | — |
| rs745360395 | 6:39,040,646 | A/G | — | uncertain significance |
| rs10305474 | 6:39,040,693 | C/T | — | benign |
| rs10305475 | 6:39,040,701 | A/G | — | benign |
| rs145619754 | 6:39,041,524 | C/T | — | uncertain significance |
| rs1768736919 | 6:39,041,528 | A/G | — | uncertain significance |
| rs761383264 | 6:39,046,130 | A/G | — | uncertain significance |
| rs761386 | 6:39,046,871 | C/G | — | — |
| rs147207725 | 6:39,046,921 | A/G | — | uncertain significance |
| rs12212036 | 6:39,047,418 | C/A | — | uncertain significance |
| rs9366994 | 6:39,048,060 | C/T | intron variant | — |
| rs146868158 | 6:39,053,718 | C/T | — | uncertain significance |
| rs201001424 | 6:39,053,737 | T/A | — | uncertain significance |
| rs189969666 | 6:39,053,803 | C/T | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.