rs10305420

This is a protein-altering variant in the GLP1R gene.

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

type 2 diabetes mellitus

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.04
p 5.0e-22
N 432,648
Major Consortium StudyLarge GWAS
European
Vujkovic M et al. “Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis.” Nature Genetics 52(7):680-691 (2020)
Allele C
OR 0.03
p 3.0e-11
N 1,114,458
Meta-analysisLarge GWAS
European

diabetes mellitus

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.04
p 2.0e-21
N 431,305
Major Consortium StudyLarge GWAS
European

HbA1c measurement

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.03
p 1.0e-15
N 492,335
Major Consortium StudyLarge GWAS
multi-ancestry

smoking initiation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)
Allele T
OR 0.01
p 1.0e-11
N 3,382,012
Large GWAS
European, East Asian, Hispanic or Latin American, African unspecified

glucose measurement

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.02
p 7.0e-14
N 601,111
Major Consortium StudyLarge GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Genetic variability in GLP-1 receptor is associated with inter-individual differences in weight lowering potential of liraglutide in obese women with PCOS: a pilot study
AssociationN=57Mojca Jensterle et al.(2015)· European Journal of Clinical Pharmacology

This pilot study investigated genetic variability in the GLP-1 receptor (GLP-1R) and its association with weight loss response to liraglutide in 57 obese women with PCOS. Carriers of at least one polymorphic rs10305420 T allele showed significantly worse treatment response (OR=0.27, P=0.025), while carriers of rs6923761 A allele tended toward better response (OR=3.06, P=0.058). The GLP-1R CA haplotype was associated with significantly better response (OR=3.85, P=0.020).

Traits studied:ObesityPCOSWeight loss response to liraglutide
PubMedDOIMetascience Observatory

About GLP1R

This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

View all GLP1R variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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