rs17690703
This is a downstream gene variant variant in the MAPT-AS1 gene.
▶GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
hippocampus molecular layer volume
Liu N et al. “Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes.” Nature Genetics 55(7):1126-1137 (2023)
Allele T
OR 0.05
p 5.0e-9
N 38,977
Large GWAS
European, East Asian
idiopathic pulmonary fibrosis
Noth I et al. “Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.” The Lancet. Respiratory Medicine 1(4):309-317 (2013)
Allele C
OR 1.43
p 6.0e-9
N 1,084
Large GWAS
European
hippocampal volume
Liu N et al. “Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes.” Nature Genetics 55(7):1126-1137 (2023)
Allele T
OR 0.05
p 1.0e-8
N 38,977
Large GWAS
European, East Asian
left ventricular structural measurement
Ning C et al. “Genome-wide association analysis of left ventricular imaging-derived phenotypes identifies 72 risk loci and yields genetic insights into hypertrophic cardiomyopathy.” Nature Communications 14(1):7900 (2023)
Allele T
OR 0.04
p 2.0e-8
N 41,286
Large GWAS
European
neutrophil count
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.03
p 7.0e-18
N 369,405
Major Consortium StudyLarge GWAS
multi-ancestry
About MAPT-AS1
Involved in regulatory ncRNA-mediated gene silencing. Implicated in Parkinson's disease. [provided by Alliance of Genome Resources, Jul 2025]
View all MAPT-AS1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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