rs17723470

This is a intron variant variant in the PRDM11 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

multinodular goiter

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.20
p 5.0e-23
N 448,210
Major Consortium StudyLarge GWAS
European

About PRDM11

Predicted to enable DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including negative regulation of cell growth; positive regulation of fibroblast apoptotic process; and regulation of DNA-templated transcription. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

View all PRDM11 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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