rs1775148

This variant is located in the SLC41A1 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

serum albumin amount

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele T

OR 0.01

p 7.0e-14

N 928,679

Large GWAS

multi-ancestry

uric acid measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele T

OR 0.02

p 2.0e-9

N 129,405

Large GWAS

East Asian

prostate carcinoma

Al Olama AA et al. “A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.” Nature Genetics 46(10):1103-9 (2014)

Allele C

OR 1.06

p 4.0e-8

N 87,040

Meta-analysisLarge GWAS

multi-ancestry

About SLC41A1

Enables magnesium:sodium antiporter activity. Involved in cellular response to magnesium ion; intracellular magnesium ion homeostasis; and magnesium ion transmembrane transport. Located in basolateral plasma membrane. Part of protein-containing complex. Implicated in nephronophthisis. [provided by Alliance of Genome Resources, Jul 2025]