rs17752199
This is a regulatory region variant variant.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
intraocular pressure measurement
Han X et al. “Association of Myopia and Intraocular Pressure With Retinal Detachment in European Descent Participants of the UK Biobank Cohort: A Mendelian Randomization Study.” Jama Ophthalmology 138(6):671-678 (2020)
Allele A
OR 0.21
p 5.0e-18
N 101,939
Major Consortium StudyLarge GWAS
European
Khawaja AP et al. “Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma.” Nature Genetics 50(6):778-782 (2018)
Allele A
OR 0.16
p 2.0e-14
N 139,555
Large GWAS
European
major depressive disorder
Als TD et al. “Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses.” Nature Medicine 29(7):1832-1844 (2023)
Allele A
OR 0.03
p 3.0e-8
N 1,349,887
Large GWAS
European
open-angle glaucoma
Han X et al. “Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci.” Nature Genetics 55(7):1116-1125 (2023)
Allele A
OR 0.18
p 2.0e-35
N 379,422
Large GWAS
European
Choquet H et al. “A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci.” Nature Communications 9(1):2278 (2018)
Allele A
OR 1.14
p 5.0e-9
N 240,302
Large GWAS
multi-ancestry
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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