rs17810546

This meta-analysis of 22,233 CAD cases and 64,762 controls tested 41 celiac disease-associated SNPs for association with coronary artery disease (CAD). While 58.5% of celiac disease risk alleles showed positive association with CAD (OR 1.001-1.081), this was not significantly different from the 50% expected by chance (p=0.069). Only rs653178 at the SH2B3/ATXN2 locus achieved study-wide statistical significance (OR 1.081, p=2.2×10⁻⁶), likely through pleiotropic effects. The findings provide no convincing evidence that genetic variants associated with celiac disease contribute to CAD risk.

This Immunochip-based genetic analysis of Behçet's disease in a Spanish population (278 cases, 1,517 controls; 130 cases, 605 controls in replication) identified HLA-B*51 as the primary susceptibility marker (P=6.82E-32, OR=3.82), with independent signals from HLA-B*57 and HLA-A*03. Outside the HLA region, the study confirmed IL23R (rs10889664: P=3.81E-12, OR=2.00), IL12A (rs1874886: P=1.62E-08, OR=1.61), and identified a novel association in the JRKL/CNTN5 region (rs2848479: P=3.29E-10, OR=1.66).

A meta-analysis of 4,107 type 2 diabetes cases and 5,187 controls from three GWA studies found no evidence that common variants altering circulating inflammatory protein levels (IL-18, IL-6R, CRP, IL1RN, PAI1, MIF) or variants predisposing to autoimmune diseases (type 1 diabetes, rheumatoid arthritis, Crohn's disease, celiac disease, multiple sclerosis, SLE) are associated with type 2 diabetes risk. For example, rs2250417 in IL18 showed OR=1.00 (95% CI 0.99-1.03) versus the expected OR of ~1.15 if inflammation were causal, suggesting inflammatory markers are likely secondary rather than causative in type 2 diabetes.