rs1790192

This is a coding sequence variant variant in the CXCR5 gene.

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Research that mentions this SNP (1)

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CXCR5 polymorphisms in non-Hodgkin lymphoma risk and prognosis
AssociationN=4,215Bridget Charbonneau et al.(2013)· Cancer Immunology, Immunotherapy

A clinic-based case-control study of 2,694 NHL cases and 1,521 controls found that five of ten CXCR5 tag SNPs were associated with non-Hodgkin lymphoma risk, with rs1790192 showing the strongest association (increased risk of follicular lymphoma). Paradoxically, rs1790192 was also associated with superior event-free survival in follicular lymphoma patients, suggesting different roles of CXCR5 in lymphoma initiation versus progression.

Traits studied:Chronic lymphocytic leukemiaDiffuse large B-cell lymphomaFollicular lymphomaMantle cell lymphomaMarginal zone lymphomaNon-Hodgkin lymphomaPeripheral T-cell lymphomaSmall lymphocytic lymphoma
PubMedDOIMetascience Observatory

About CXCR5

This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

View all CXCR5 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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