CXCR5
C-X-C motif chemokine receptor 5
Summary
This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Known Variants28 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs630923 | 11:118,754,353 | C/A | regulatory region variant | benign |
| rs376334978 | 11:118,754,678 | G/A | — | uncertain significance |
| rs1790192 | 11:118,757,191 | G/C | coding sequence variant | — |
| rs187437652 | 11:118,758,925 | C/T | regulatory region variant | — |
| rs11574669 | 11:118,764,298 | C/G | — | benign |
| rs146150938 | 11:118,764,331 | C/G | — | uncertain significance |
| rs148564775 | 11:118,764,413 | G/T | — | uncertain significance |
| rs774152337 | 11:118,764,449 | G/A | — | likely benign |
| rs375559046 | 11:118,764,536 | G/A | — | uncertain significance |
| rs144650313 | 11:118,764,575 | G/A | — | uncertain significance |
| rs2496648257 | 11:118,764,608 | A/G | — | uncertain significance |
| rs1055244370 | 11:118,764,631 | T/G | — | uncertain significance |
| rs373196739 | 11:118,764,713 | G/A | — | uncertain significance |
| rs1044832671 | 11:118,764,834 | A/T | — | uncertain significance |
| rs2230320 | 11:118,765,081 | C/T | — | benign |
| rs145276178 | 11:118,765,085 | G/A | — | uncertain significance |
| rs769274153 | 11:118,765,121 | G/A | — | uncertain significance |
| rs776993079 | 11:118,765,127 | A/G | — | uncertain significance |
| rs766477033 | 11:118,765,157 | G/A | — | uncertain significance |
| rs187389271 | 11:118,765,165 | C/T | — | likely benign |
| rs371145208 | 11:118,765,171 | G/A | — | uncertain significance |
| rs1436162948 | 11:118,765,196 | T/A | — | uncertain significance |
| rs144033290 | 11:118,765,232 | G/A | — | uncertain significance |
| rs140843011 | 11:118,765,257 | G/A | — | uncertain significance |
| rs1038959105 | 11:118,765,274 | G/T | — | uncertain significance |
| rs142644535 | 11:118,765,320 | G/T | — | uncertain significance |
| rs748488358 | 11:118,765,331 | C/T | — | uncertain significance |
| rs3922 | 11:118,765,600 | A/G | 3 prime UTR variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.