rs1800683
This is a regulatory region variant variant in the LTA gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
tumor necrosis factor receptor superfamily member 1B amount
▶Research that mentions this SNP (1)
▶Association of lymphotoxin‐alpha gene polymorphisms (rs909253, rs1800683 and rs2229094) and risk of large‐artery atherosclerosis stroke in Iranian populationAssociationAli Fasihi et al.(2020)· The Journal of Gene Medicine
Fasihi et al. investigated the association between three lymphotoxin-alpha (LTA) gene polymorphisms (rs909253, rs1800683, and rs2229094) and the risk of large-artery atherosclerosis stroke in an Iranian population. This case-control genetic association study examined whether these LTA variants contribute to stroke susceptibility in the Iranian cohort.
About LTA
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
View all LTA variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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