LTA
lymphotoxin alpha
Summary
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
Known Variants33 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs28445017 | 6:31,527,756 | G/A | regulatory region variant | — |
| rs2516392 | 6:31,529,334 | C/G | downstream gene variant | — |
| rs28732143 | 6:31,530,810 | G/C | — | — |
| rs928815 | 6:31,531,215 | T/A | — | — |
| rs7762619 | 6:31,531,310 | T/G | regulatory region variant | — |
| rs3135043 | 6:31,532,193 | G/A | intergenic variant | — |
| rs185288821 | 6:31,532,292 | C/T | intergenic variant | — |
| rs2857602 | 6:31,533,378 | G/C | — | — |
| rs2857708 | 6:31,533,606 | C/T | intergenic variant | — |
| rs9267497 | 6:31,534,500 | A/G | intergenic variant | — |
| rs190775951 | 6:31,535,133 | G/A | upstream gene variant | — |
| rs2844484 | 6:31,536,224 | A/T | — | — |
| rs2009658 | 6:31,538,244 | C/G | upstream gene variant | — |
| rs915654 | 6:31,538,497 | T/C | — | — |
| rs2844482 | 6:31,539,767 | C/T | regulatory region variant | — |
| rs2071590 | 6:31,539,768 | A/G | regulatory region variant | — |
| rs1800683 | 6:31,540,071 | G/A | regulatory region variant | — |
| rs2239704 | 6:31,540,141 | A/G | — | risk factor |
| rs909253 | 6:31,540,313 | A/G | regulatory region variant | risk factor |
| rs746868 | 6:31,540,429 | C/G | regulatory region variant | — |
| rs2229094 | 6:31,540,556 | T/C | missense variant | benign |
| rs2533225720 | 6:31,540,763 | A/G | — | uncertain significance |
| rs765801422 | 6:31,540,783 | A/G | — | uncertain significance |
| rs1041981 | 6:31,540,784 | C/A | missense variant | risk factor |
| rs1196374898 | 6:31,540,797 | T/C | — | likely benign |
| rs370300245 | 6:31,541,168 | A/G | — | uncertain significance |
| rs1455720799 | 6:31,541,177 | G/A | — | uncertain significance |
| rs201957060 | 6:31,541,274 | A/C | — | uncertain significance |
| rs2533230278 | 6:31,541,363 | G/A | — | uncertain significance |
| rs1799964 | 6:31,542,308 | T/C | regulatory region variant | — |
| rs1800630 | 6:31,542,476 | C/A | downstream gene variant | protective |
| rs1799724 | 6:31,542,482 | C/T | downstream gene variant | risk factor |
| rs4248158 | 6:31,542,533 | C/T | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.