rs2857602

This variant is located in the LTA gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

mucocutaneous lymph node syndrome

Johnson TA et al. “Association of an IGHV3-66 gene variant with Kawasaki disease.” Journal of Human Genetics 66(5):475-489 (2021)

Allele A

OR 0.78

p 3.0e-15

N 6,362

Large GWAS

East Asian

tumor necrosis factor amount

Yuan S et al. “Effects of tumour necrosis factor on cardiovascular disease and cancer: A two-sample Mendelian randomization study.” Ebiomedicine 59:102956 (2020)

Allele G

OR 0.03

p 3.0e-12

N 30,912

Large GWAS

European

psoriasis

Zhang M et al. “Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis.” Journal of Translational Medicine 23(1):133 (2025)

Allele A

OR 0.07

p 9.0e-11

N 472,819

Meta-analysisLarge GWAS

multi-ancestry

About LTA

The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]