rs4248158
This is a regulatory region variant variant in the LTA gene.
▶Research that mentions this SNP (1)
▶Influence of polymorphisms and TNF and IL1β serum concentration on the infliximab response in Crohn’s disease and ulcerative colitisAssociationN=47Diana Lacruz-Guzmán et al.(2013)· European Journal of Clinical Pharmacology
First study evaluating the pharmacogenetic role of rs1143634 IL1B polymorphism and TNF promoter polymorphisms in infliximab-treated inflammatory bowel disease patients. Found rs1143634 C allele associated with higher serum IL1β concentrations (p=0.0345) and lower response to infliximab in Crohn's disease (p=0.027 for clinical remission). No significant associations found with TNF polymorphisms.
About LTA
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
View all LTA variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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