rs1800925

This case-control association study examined HLA-DQ rs9275596, IL13 rs20541, and IL13 rs1800925 polymorphisms in 378 shrimp-allergic patients and 125 controls from West Bengal, India. Risk genotypes HLA-DQ rs9275596 CC (OR=2.88, P=0.04), IL13 rs20541 AA (OR=3.60, P=0.01), and IL13 rs1800925 TT (OR=5.48, P=0.03) were significantly associated with challenge-proven shrimp allergy and elevated shrimp-specific IgE levels. The IL13 TA haplotype showed significant association with shrimp allergy and had synergistic effects with the HLA-DQ CC genotype in elevating specific IgE (P=0.03).

This case-control study analyzes 28 SNPs in 26 inflammatory response genes in 343 patients (100 with appendicitis, 243 controls) using TaqMan genotyping. Significant associations were found for IL-13 rs1800925 (OR=6.02, 95% CI 1.52-23.78), IL-17 rs2275913 (OR=2.38, 95% CI 1.24-4.57), and CCL22 rs223888 (OR=0.12, 95% CI 0.02-0.90), suggesting a genetic-driven inflammatory response as a pathogenic mechanism in appendicitis.

A meta-analysis of 21 case-control studies examining IL-13 and CD14 gene polymorphisms in allergic rhinitis (AR). The A allele of IL-13 SNP rs20541 was significantly associated with increased AR risk in Asians (OR 1.21, 95% CI 1.11-1.32, P<0.001) but not in Caucasians. No significant associations were found for IL-13 rs1800925 or CD14 rs2569190 with AR risk in either ethnic group.

This pharmacogenetic study of 374 patients with metastatic renal cell carcinoma examined SNP associations with sunitinib-induced toxicity. The IL8 rs1126647 T allele was associated with increased hypertension risk (OR=1.69, P=0.024), and the IL13 rs1800925 T allele was associated with increased leukopenia (OR=6.76, P=0.020) and grade >2 toxicity (OR=1.75, P=0.028). No significant associations were found with progression-free survival, overall survival, or clinical response.

Population-based case-control study of Connecticut women showing that genetic polymorphisms in IL10RA (rs9610) and TNF (rs1800629) genes modify the association between blood transfusion and non-Hodgkin lymphoma (NHL) risk. IL10RA rs9610 GG genotype carriers with transfusion history had increased NHL risk (OR=1.9, 95% CI: 1.1-3.2), while AG/AA carriers had decreased risk (OR=0.6, 95% CI: 0.4-0.9), with significant gene-transfusion interaction (P=0.003).

A case-control study of 127 multiple myeloma (MM) cases and 545 controls examined 82 common variants in 45 genes mediating immunity. IL4R rs2107356 (−28120T homozygotes, OR=1.91, 95% CI 1.08-3.38) and FCGR2A rs1801274 (−120G homozygotes, OR=1.95, 95% CI 1.06-3.60) were significantly associated with increased MM risk. A haplotype in the LTA*TNF complex (LTA −82C/−90G*TNF −1036C/−487G/−417G, OR=1.63, 95% CI 1.02-2.61) was also associated with increased MM risk compared to controls.

This case-control study evaluated four IL13 gene polymorphisms (rs1800925, rs847, rs20541, and rs2243204) in 107 systemic sclerosis (SSc) patients and 170 controls. Two IL13 polymorphisms were associated with SSc: rs1800925 (IL13-1055) and rs2243204 showed associations in both total and diffuse cutaneous SSc populations (p=0.03-0.04). The rs2243204 T allele was more frequent in SSc patients overall (OR=2.3, 95% CI 1.21-4.38) and in diffuse cutaneous SSc (OR=2.95, 95% CI 1.35-6.49), suggesting IL13 polymorphisms may contribute to SSc susceptibility and phenotypic expression.