IL13
interleukin 13
Summary
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
Known Variants20 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs3091308 | 5:131,991,032 | G/T | — | — |
| rs12188917 | 5:131,991,085 | T/C | upstream gene variant | — |
| rs1881457 | 5:131,992,409 | A/C | regulatory region variant | — |
| rs1800925 | 5:131,992,809 | C/T | upstream gene variant | risk factor |
| rs11575055 | 5:131,992,905 | C/T | — | — |
| rs2069743 | 5:131,993,275 | A/G | upstream gene variant | — |
| rs200168712 | 5:131,993,886 | C/T | — | likely benign |
| rs1358582586 | 5:131,993,997 | C/G | — | uncertain significance |
| rs34255686 | 5:131,994,031 | C/A | — | benign |
| rs2066960 | 5:131,994,435 | C/A | intron variant | — |
| rs1295687 | 5:131,994,462 | C/A | — | — |
| rs2069744 | 5:131,994,669 | C/T | intron variant | — |
| rs553444004 | 5:131,995,426 | C/T | — | uncertain significance |
| rs1295686 | 5:131,995,843 | T/C | regulatory region variant | — |
| rs961082728 | 5:131,995,858 | G/T | — | likely benign |
| rs140828306 | 5:131,995,889 | G/A | — | benign |
| rs200247901 | 5:131,995,959 | G/T | — | uncertain significance |
| rs20541 | 5:131,995,964 | A/G | missense variant | risk factor |
| rs1295685 | 5:131,996,445 | A/T | — | — |
| rs848 | 5:131,996,500 | A/G | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.