rs181265966

This variant is located in the PRR12 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Hodgkins lymphoma

Osman Y et al. “Functional multigenic variations associated with hodgkin lymphoma.” International Journal of Laboratory Hematology 43(6):1472-1482 (2021)

Allele A

OR —

β 0.036

p 2.0e-11

N 97

Small GWAS

Greater Middle Eastern (Middle Eastern, North African or Persian)

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ClinVar annotation

Likely Benign★★★☆

3 submitters

Inborn genetic diseases; PRR12-related disorder; not provided

View on ClinVar →

About PRR12

This gene encodes a proline-rich protein that contains two A-T hook DNA binding domains. A chromosomal translocation and gene fusion between this gene and zinc finger, MIZ-type containing 1 (Gene ID: 57178) may underlie intellectual disability and neuropsychiatric problems in a human patient. Enriched expression of this gene in embryonic mouse brain suggests that this gene may play a role in nervous system development. [provided by RefSeq, Jul 2016]

View all PRR12 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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